Urothelial Carcinoma by Wolfgang A Schulz Michèle J. Hoffmann & Günter Niegisch

Author:Wolfgang A Schulz, Michèle J. Hoffmann & Günter Niegisch
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

1.6 Genetically Engineered Model of Urothelial Cancer

Activation of oncogenes such as H-Ras or loss of function in tumor suppressor genes such as RB1 and TP53 in the urothelium is considered critical for the development of urothelial tumors [26, 27]. These alterations can be exploited to generate genetically engineered models (GEM) of bladder cancer. GEMs are now used widely for many applications in cancer biology, including analyses of tumor phenotypes , modeling disease subtypes, mechanistic investigations of candidate genes and signaling pathways, and preclinical evaluation of potential therapeutic agents [28–30]. GEM models complement non-autochthonous mouse models, as tumors arise de novo in the native tissue microenvironment, and they also complement carcinogen -based models, as they are based on defined genetic alterations.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.